Ammonia inhibits cAMP-regulated intestinal Cl- transport. Asymmetric effects of apical and basolateral exposure and implications for epithelial barrier function.

The colon, unlike most organs, is normally exposed to high concentrations of ammonia, a weak base which exerts profound and diverse biological effects on mammalian cells. The impact of ammonia on intestinal cell function is largely unknown despite its concentration of 4-70 mM in the colonic lumen. T...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Prasad, M, Smith, J A, Resnick, A, Awtrey, C S, Hrnjez, B J, Matthews, J B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7593599/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118268
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