Selective blockade of phosphodiesterase types 2, 5 and 9 results in cyclic 3′5′ guanosine monophosphate accumulation in retinal pigment epithelium cells

AIM: To investigate which phosphodiesterase (PDE) is involved in regulating cyclic 3′5′ guanosine monophosphate breakdown in retinal pigment epithelium (RPE) cells. METHODS: cGMP content in the cultured RPE cells (D407 cell line) was evaluated by immunocytochemistry in the presence of non‐selective...

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Detalhes bibliográficos
Main Authors: Diederen, R M H, Heij, E C La, Ittersum, M Markerink‐van, Kijlstra, A, Hendrikse, F, de Vente, J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Laboratory Science - Extended Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857670/
https://ncbi.nlm.nih.gov/pubmed/16943225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bjo.2006.100628
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