Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons

In cultured cerebrocortical neurons, mild excitotoxic insults or staurosporine result in apoptosis. We show here that N-methyl-d-aspartate (NMDA) receptor-mediated, but not staurosporine-mediated, apoptosis is preceded by depolarization of the mitochondrial membrane potential (Δψ(m)) and ATP loss. B...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Budd, Samantha L., Tenneti, Lalitha, Lishnak, Timothy, Lipton, Stuart A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100121097
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