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Characterization of ATP independent ERK inhibitors identified through in silico analysis of the active ERK2 structure.
The extracellular signal regulated kinases (ERK1 and ERK2) are important mediators of cell proliferation. Constitutive activation of the ERK proteins plays a critical role in the proliferation of many human cancers. Taking advantage of recently identified substrate docking domains on ERK2, we have u...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1857279/ https://ncbi.nlm.nih.gov/pubmed/17000106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.09.038 |
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