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Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding

BACKGROUND AND AIMS: Tissue transglutaminase (tTG) is an autoantigen in coeliac disease and the related disorder, dermatitis herpetiformis. The detection of autoantibodies directed against tTG is a highly specific marker of coeliac disease; however, it is unclear if there is a role for these autoant...

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Detalhes bibliográficos
Main Authors: Byrne, Greg, Ryan, Fergus, Jackson, John, Feighery, Con, Kelly, Jacinta
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856828/
https://ncbi.nlm.nih.gov/pubmed/16935926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.092908
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