7-Hydroxytropolone: an inhibitor of aminoglycoside-2"-O-adenylyltransferase.

Aminoglycoside-2"-O-adenylyltransferase was inhibited by 7-hydroxytropolone. Inhibition was competitive with respect to the cosubstrate ATP and appeared to require the unique vicinal arrangement of oxygens found in 7-hydroxytropolone. Combinations of 7-hydroxytropolone plus the appropriate aminoglyc...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Allen, N E, Alborn, W E, Hobbs, J N, Kirst, H A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1982
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185667/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6185088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.22.5.824
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