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Tumor Necrosis Factor-alpha Damages Tumor Blood Vessel Integrity by Targeting VE-Cadherin
BACKGROUND: Isolated limb perfusion using high-dose human tumor necrosis factor-alpha with melphalan is effective therapy for bulky extremity in-transit melanoma and sarcoma. OBJECTIVE: While it is widely accepted that melphalan is a DNA alkylating agent, the mechanism of selective antitumor effect...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1856603/ https://ncbi.nlm.nih.gov/pubmed/17060772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.sla.0000231723.81218.72 |
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