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Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis

BACKGROUND AND AIMS: Activated pancreatic stellate cells (PSCs) are implicated in the production of alcohol induced pancreatic fibrosis. PSC activation is invariably associated with loss of cytoplasmic vitamin A (retinol) stores. Furthermore, retinol and ethanol are known to be metabolised by simila...

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Detalhes bibliográficos
Main Authors: McCarroll, J A, Phillips, P A, Santucci, N, Pirola, R C, Wilson, J S, Apte, M V
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1856372/
https://ncbi.nlm.nih.gov/pubmed/16043492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.064543
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