Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.

Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor v...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Trousdale, M D, Gordon, Y J, Peters, A C, Gropen, T I, Nelson, E, Nesburn, A B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185570/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6329084/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.25.4.522
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