Covalent Dimer Species of β-Defensin Defr1 Display Potent Antimicrobial Activity against Multidrug-Resistant Bacterial Pathogens

Beta defensins comprise a family of cationic, cysteine-rich antimicrobial peptides, predominantly expressed at epithelial surfaces. Previously we identified a unique five-cysteine defensin-related peptide (Defr1) that, when synthesized, is a mixture of dimeric isoforms and exhibits potent antimicrob...

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Main Authors: Taylor, Karen, McCullough, Bryan, Clarke, David J., Langley, Ross J., Pechenick, Tali, Hill, Adrian, Campopiano, Dominic J., Barran, Perdita E., Dorin, Julia R., Govan, John R. W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2007
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855538/
https://ncbi.nlm.nih.gov/pubmed/17353239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01531-06
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