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Mechanism of the myosin catalyzed hydrolysis of ATP as rationalized by molecular modeling

The intrinsic chemical reaction of adenosine triphosphate (ATP) hydrolysis catalyzed by myosin is modeled by using a combined quantum mechanics and molecular mechanics (QM/MM) methodology that achieves a near ab initio representation of the entire model. Starting with coordinates derived from the he...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Grigorenko, Bella L., Rogov, Alexander V., Topol, Igor A., Burt, Stanley K., Martinez, Hugo M., Nemukhin, Alexander V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855422/
https://ncbi.nlm.nih.gov/pubmed/17438284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701727104
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