MHC class II deprivation impairs CD4 T cell motility and responsiveness to antigen-bearing dendritic cells in vivo

The role continuous contact with self-peptide/MHC molecules (self ligands) in the periphery plays in the function of mature T cells remains unclear. Here, we elucidate a role for MHC class II molecules in T cell trafficking and antigen responsiveness in vivo. We find that naïve CD4 T cells deprived...

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Detalhes bibliográficos
Main Authors: Fischer, Ursula B., Jacovetty, Erica L., Medeiros, Ricardo B., Goudy, Brian D., Zell, Traci, Swanson, Jeannie-Beth, Lorenz, Elizabeth, Shimizu, Yoji, Miller, Mark J., Khoruts, Alexander, Ingulli, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855382/
https://ncbi.nlm.nih.gov/pubmed/17435166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608299104
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