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Cre-loxP-Mediated Recombination between the SIL and SCL Genes Leads to a Block in T-Cell Development at the CD4(-)CD8(-) to CD4(+)CD8(+) Transition

In the most common form of stem cell leukemia (SCL) gene rearrangement, an interstitial deletion of 82 kb brings SCL under the control of regulatory elements that normally govern expression of the ubiquitously expressed SCL interrupting locus (SIL) gene, which is located directly upstream of SCL. To...

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Bibliografiske detaljer
Main Authors: Yue Cheng, Zhenhua Zhang, Slape, Christopher, Aplan, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854848/
https://ncbi.nlm.nih.gov/pubmed/17460775
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