Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus.

Streptomyces erythreus produces erythromycin, presumably from methylmalonyl-coenzyme A (CoA), which could be generated by the isomerization of succinyl-CoA. In S. erythreus cultures, [1,4-14C,2,3-3H]succinate was incorporated into erythromycin with a doubling of the 3H/14C ratio. This result is cons...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Hunaiti, A A, Kolattukudy, P E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1984
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185468/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6143534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.25.2.173
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