Alveolar macrophages and eicosanoids but not neutrophils, mediate bronchoconstriction induced by FMLP in the guinea-pig.

1. N-formyl-methionyl-leucyl-phenylalanine (FMLP), when administered by aerosol to guinea-pigs, induced a dose-dependent bronchoconstriction (BC) with no overt effect on platelet and leukocyte blood counts. Repeated administration of FMLP by aerosol was followed by desensitization. 2. Electron micro...

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Bibliographic Details
Main Authors: Boukili, M. A., Bureau, M. F., Lellouch-Tubiana, A., Lefort, J., Simon, M. T., Vargaftig, B. B.
Format: Artigo
Language:Inglês
Published: 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854669/
https://ncbi.nlm.nih.gov/pubmed/2508985
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