Histamine H3-receptors inhibit cholinergic neurotransmission in guinea-pig airways.

The histamine H3-agonist (R)-alpha-methylhistamine (alpha-MeHA) caused a dose-dependent inhibition of vagally-mediated contraction of a guinea-pig tracheal tube preparation but did not alter tracheal contraction induced by exogenously-applied acetylcholine. Blockade of H1- and H2-histamine receptors...

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Main Authors: Ichinose, M., Stretton, C. D., Schwartz, J. C., Barnes, P. J.
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1854483/
https://ncbi.nlm.nih.gov/pubmed/2541854
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