Antinociception induced by systemic administration of local anaesthetics depends on a central cholinergic mechanism.

1 The antinociceptive effects of systemically-administered procaine, lignocaine and bupivacaine were examined in mice and rats by using the hot-plate, writhing and tail flick tests. 2 In both species all three local anaesthetics produced significant antinociception which was prevented by atropine (5...

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Main Authors: Bartolini, A., Galli, A., Ghelardini, C., Giotti, A., Malcangio, M., Malmberg-Aiello, P., Zucchi, P. L.
Format: Artigo
Sprog:Inglês
Udgivet: 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853732/
https://ncbi.nlm.nih.gov/pubmed/3427277
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