5-fluorocytosine susceptibility of pathogenic fungi in the presence of allopurinol: potential for improving the therapeutic index of 5-fluorocytosine.

The minimal inhibitory concentration of 5-fluorocytosine in 18 pathogenic fungal isolates was not altered by either allopurinol (100 microM) or oxypurinol (100 microM). Since allopurinol at this level clinically has been demonstrated to interfere with 5-fluorouracil anabolism, thereby reducing toxic...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Kerkering, T M, Schwartz, P M, Espinel-Ingroff, A, Turek, P J, Diasio, R B
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185345/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6639003/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.24.3.448
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