Novel Approach to Specific Growth Factor Inhibition in Vivo : Antagonism of Platelet-Derived Growth Factor in Glomerulonephritis by Aptamers

Mesangial cell proliferation and matrix accumulation, driven by platelet-derived growth factor (PDGF), contribute to many progressive renal diseases. In a novel approach to antagonize PDGF, we investigated the effects of a nuclease-resistant high-affinity oligonucleotide aptamer in vitro and in vivo...

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Hauptverfasser: Floege, Jürgen, Ostendorf, Tammo, Janssen, Ulf, Burg, Michael, Radeke, Heinfried H., Vargeese, Chandra, Gill, Stanley C., Green, Louis S., Janjic, Nebojsa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 1999
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853442/
https://ncbi.nlm.nih.gov/pubmed/9916931
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