Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease association with p-values between 10(−6) and 10(−...

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Main Authors: Libioulle, Cécile, Louis, Edouard, Hansoul, Sarah, Sandor, Cynthia, Farnir, Frédéric, Franchimont, Denis, Vermeire, Séverine, Dewit, Olivier, de Vos, Martine, Dixon, Anna, Demarche, Bruno, Gut, Ivo, Heath, Simon, Foglio, Mario, Liang, Liming, Laukens, Debby, Mni, Myriam, Zelenika, Diana, Gossum, André Van, Rutgeerts, Paul, Belaiche, Jacques, Lathrop, Mark, Georges, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853118/
https://ncbi.nlm.nih.gov/pubmed/17447842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030058
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