Transfer of Tumor Necrosis Factor-α to Rat Lung Induces Severe Pulmonary Inflammation and Patchy Interstitial Fibrogenesis with Induction of Transforming Growth Factor-β1 and Myofibroblasts

Tumor necrosis factor-α is up-regulated in a variety of different human immune-inflammatory and fibrotic pulmonary pathologies. However, its precise role in these pathologies and, in particular, the mechanism(s) by which it may induce fibrogenesis are not yet elucidated. Using a replication-deficien...

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Autores principales: Sime, Patricia J., Marr, Robert A., Gauldie, David, Xing, Zhou, Hewlett, Bryan R., Graham, Frank L., Gauldie, Jack
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 1998
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1853002/
https://ncbi.nlm.nih.gov/pubmed/9736031
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