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Late-Onset Chronic Inflammatory Encephalopathy in Immune-Competent and Severe Combined Immune-Deficient (SCID) Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor

To examine the role of tumor necrosis factor (TNF)-α in the pathogenesis of degenerative disorders of the central nervous system (CNS), transgenic mice were developed in which expression of murine TNF-α was targeted to astrocytes using a glial fibrillary acidic protein (GFAP)-TNF-α fusion gene. In t...

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Detalhes bibliográficos
Main Authors: Stalder, Anna K., Carson, Monica J., Pagenstecher, Axel, Asensio, Valerie C., Kincaid, Carrie, Benedict, Megan, Powell, Henry C., Masliah, Eliezer, Campbell, Iain L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852999/
https://ncbi.nlm.nih.gov/pubmed/9736027
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