Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu).

Type III hyperlipoproteinemia is characterized by delayed chylomicron and VLDL remnant catabolism and is associated with homozygosity for the apoE-2 allele. We have identified a kindred in which heterozygosity for an apoE mutant, apoE-1 (Lys146-->Glu), is dominantly associated with the expression of...

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Pubblicato in:	J Clin Invest
Autori principali:	Mann, W A, Lohse, P, Gregg, R E, Ronan, R, Hoeg, J M, Zech, L A, Brewer, H B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7635945/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118096
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