Accelerated Loss of Islet β Cells in Sucrose-Fed Goto-Kakizaki Rats, a Genetic Model of Non-Insulin-Dependent Diabetes Mellitus

The Goto-Kakizaki (GK) rat is a spontaneously diabetic animal model of non-insulin-dependent diabetes mellitus, which is characterized by progressive loss of β cells in the pancreatic islets with fibrosis. In the present study, we examined the effects of sucrose feeding on the islet pathology in thi...

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Main Authors: Koyama, Motoi, Wada, Ryu-ichi, Sakuraba, Hiroyasu, Mizukami, Hiroki, Yagihashi, Soroku
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852987/
https://ncbi.nlm.nih.gov/pubmed/9708813
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