Genetic Aberrations in Hypodiploid Breast Cancer : Frequent Loss of Chromosome 4 and Amplification of Cyclin D1 Oncogene

The evolution of somatic genetic aberrations in breast cancer has remained poorly understood. The most common chromosomal abnormality is hyperdiploidy, which is thought to arise via a transient hypodiploid state. However, hypodiploidy persists in 1 to 2% of breast tumors, which are characterized by...

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Main Authors: Tanner, Minna M., Karhu, Ritva A., Nupponen, Nina N., Borg, Åke, Baldetorp, Bo, Pejovic, Tanja, Fernö, Mårten, Killander, Dick, Isola, Jorma J.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852954/
https://ncbi.nlm.nih.gov/pubmed/9665480
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