Long-Term, Near-Total Liver Replacement by Transplantation of Isolated Hepatocytes in Rats Treated with Retrorsine

Genetically marked hepatocytes from dipeptidyl peptidase (DPP) IV(+) Fischer 344 rats were transplanted into the liver of DPPIV(−) mutant Fischer 344 rats after a combined treatment with retrorsine, a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, and two-thirds partial hepatectomy. I...

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Main Authors: Laconi, Ezio, Oren, Ran, Mukhopadhyay, Deb K., Hurston, Ethel, Laconi, Sergio, Pani, Paolo, Dabeva, Mariana D., Shafritz, David A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 1998
Teme:
Animal Model
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852941/
https://ncbi.nlm.nih.gov/pubmed/9665494
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