Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism

Tyrosinase is a melanocyte-specific enzyme critical for the synthesis of melanin, a process normally restricted to a post-Golgi compartment termed the melanosome. Loss-of-function mutations in tyrosinase are the cause of oculocutaneous albinism, demonstrating the importance of the enzyme in pigmenta...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Halaban, Ruth, Svedine, Sherri, Cheng, Elaine, Smicun, Yoel, Aron, Rebecca, Hebert, Daniel N.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823941/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.11.5889
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