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Functional interactions of DNA topoisomerases with a human replication origin
The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner. The topoisomerases interact in vivo and in vitro with precise bonds ahead of the start sites of bidirectional replication, within the pre-replicative compl...
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Main Authors: | , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
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Nature Publishing Group
2007
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Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1852844/ https://ncbi.nlm.nih.gov/pubmed/17290216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601578 |
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