The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth

Somatotrophs are the only pituitary cells that express Ret, GFRα1 and GDNF. This study investigated the effects of Ret in a somatotroph cell line, in primary pituitary cultures and in Ret KO mice. Ret regulates somatotroph numbers by inducing Pit-1 overexpression, leading to increased p53 expression...

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Detalhes bibliográficos
Main Authors: Cañibano, Carmen, Rodriguez, Noela L, Saez, Carmen, Tovar, Sulay, Garcia-Lavandeira, Montse, Borrello, Maria Grazia, Vidal, Anxo, Costantini, Frank, Japon, Miguel, Dieguez, Carlos, Alvarez, Clara V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852774/
https://ncbi.nlm.nih.gov/pubmed/17380130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601636
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