JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo

Our previous studies demonstrated that sulindac, a non-steroidal anti-inflammatory drug, suppressed intestinal tumor formation in mouse, which is linked to the induction of wild-type p53-activated fragment 1 (p21WAF1, or p21). Here we showed that sulindac also required c-jun N-terminal Kinase 1 (JNK...

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Bibliografiske detaljer
Main Authors: Song, Zibo, Tong, Chang, Liang, Jiao, Dockendorff, Ashley, Huang, Chuanshu, Augenlicht, Leonard H, Yang, Wancai
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852492/
https://ncbi.nlm.nih.gov/pubmed/17292881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2007.01.020
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