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An In Vitro Model of Human Dopaminergic Neurons Derived from Embryonic Stem Cells: MPP(+) Toxicity and GDNF Neuroprotection

Human embryonic stem cells (hESCs) can proliferate indefinitely yet also differentiate in vitro, allowing normal human neurons to be generated in unlimited numbers. Here, we describe the development of an in vitro neurotoxicity assay using human dopaminergic neurons derived from hESCs. We showed tha...

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Detalhes bibliográficos
Main Authors: Zeng, Xianmin, Chen, Jia, Deng, Xiaolin, Liu, Ying, Rao, Mahendra S., Cadet, Jean-Lud, Freed, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852423/
https://ncbi.nlm.nih.gov/pubmed/17109014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.npp.1301125
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