Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma

The mechanisms by which multiple myeloma (MM) cells migrate and home to the bone marrow are not well understood. In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and its receptor CXCR4 on the migration and homing of MM cells. We demonstrated that CXCR4 is differential...

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Hlavní autoři: Alsayed, Yazan, Ngo, Hai, Runnels, Judith, Leleu, Xavier, Singha, Ujjal K., Pitsillides, Costas M., Spencer, Joel A., Kimlinger, Teresa, Ghobrial, Joanna M., Jia, Xiaoying, Lu, Ganwei, Timm, Michael, Kumar, Ashok, Côté, Daniel, Veilleux, Israel, Hedin, Karen E., Roodman, G. David, Witzig, Thomas E., Kung, Andrew L., Hideshima, Teru, Anderson, Kenneth C., Lin, Charles P., Ghobrial, Irene M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2007
Témata:
Chemokines, Cytokines, and Interleukins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852222/
https://ncbi.nlm.nih.gov/pubmed/17119115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-035857
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