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Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34 protein in primary human hematopoietic progenitors from bone marrow

We have previously shown that engagement of the integrins VLA-4 and VLA-5 to the fibronectin fragment CH-296 in combination with cytokines sustained the capacity of cultured human CD34(+) cells to undergo hematopoiesis in immunodeficient mice for 7 to 12 months, whereas this capacity was rapidly los...

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Bibliographic Details
Main Authors: Dao, Mo A., Nolta, Jan A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852192/
https://ncbi.nlm.nih.gov/pubmed/17095623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-026039
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