In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study

BACKGROUND: Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which acts as a chloride channel activated by cyclic AMP (cAMP). The most frequent mutation found in 70% of CF patients is F508del, while premature sto...

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Autori principali: Sermet-Gaudelus, Isabelle, Renouil, Michel, Fajac, Anne, Bidou, Laure, Parbaille, Bastien, Pierrot, Sébastien, Davy, Nolwen, Bismuth, Elise, Reinert, Philippe, Lenoir, Gérard, Lesure, Jean François, Rousset, Jean Pierre, Edelman, Aleksander
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852113/
https://ncbi.nlm.nih.gov/pubmed/17394637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-5-5
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