Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine.

We have generated an IgG1 murine monoclonal anti-idiotype antibody (Ab2) designated 3H1, which mimics a specific epitope on the carcinoembryonic antigen (CEA). Patients with CEA positive tumors are immunologically "tolerant" to CEA. We used 3H1 as a surrogate for CEA for vaccine therapy of 12 patien...

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Pubblicato in:	J Clin Invest
Autori principali:	Foon, K A, Chakraborty, M, John, W J, Sherratt, A, Köhler, H, Bhattacharya-Chatterjee, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7615803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118039
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