Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

Endothelin-1 (ET-1) is a 21-amino acid peptide with various biological activities including vasoconstriction and cell proliferation. To clarify the physiological and pathophysiological role of ET-1, we disrupted the mouse Edn1 locus encoding ET-1 by gene targeting and demonstrated that ET-1 is essen...

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Bibliografiske detaljer
Main Authors: Kurihara, Y, Kurihara, H, Oda, H, Maemura, K, Nagai, R, Ishikawa, T, Yazaki, Y
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC185200/
https://ncbi.nlm.nih.gov/pubmed/7615798
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