Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.

The murine TNF-alpha gene was expressed under the control of the human surfactant protein SP-C promoter in transgenic mice. A number of the SP-C TNF-alpha mice died at birth or after a few weeks with very severe lung lesions. Surviving mice transmitted a pulmonary disease to their offspring, the sev...

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Autori principali: Miyazaki, Y, Araki, K, Vesin, C, Garcia, I, Kapanci, Y, Whitsett, J A, Piguet, P F, Vassalli, P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC185196/
https://ncbi.nlm.nih.gov/pubmed/7542280
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