A Second-Site Suppressor Significantly Improves the Defective Phenotype Imposed by Mutation of an Aromatic Residue in the N-terminal Domain of the HIV-1 Capsid Protein

The HIV-1 capsid (CA) protein plays an important role in virus assembly and infectivity. Previously we showed that Ala substitutions in the N-terminal residues Trp23 and Phe40 cause a severely defective phenotype. In searching for mutations at these positions that result in a non-lethal phenotype, w...

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Main Authors: Tang, Shixing, Ablan, Sherimay, Dueck, Megan, Ayala-López, Wilfredo, Soto, Brenda, Caplan, Margaret, Nagashima, Kunio, Hewlett, Indira K., Freed, Eric O., Levin, Judith G.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851891/
https://ncbi.nlm.nih.gov/pubmed/17055023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.09.027
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