Altered Expression of Galectin-3 Induces Cortical Thymocyte Depletion and Premature Exit of Immature Thymocytes during Trypanosoma cruzi Infection

During acute infection with Trypanosoma cruzi, the causative agent of Chagas’ disease, the thymus undergoes intense atrophy followed by a premature escape of CD4(+)CD8(+) immature cortical thymocytes. Here we report a pivotal role for the endogenous lectin galectin-3 in accelerating death of thymocy...

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Main Authors: Silva-Monteiro, Elizangela, Reis Lorenzato, Luciana, Kenji Nihei, Oscar, Junqueira, Mara, Rabinovich, Gabriel Adrián, Hsu, Daniel Kaiyuan, Liu, Fu-Tong, Savino, Wilson, Chammas, Roger, Villa-Verde, Déa Maria Serra
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2007
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851869/
https://ncbi.nlm.nih.gov/pubmed/17255323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060389
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