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Hypoxia Inducible Factor-1 Mediates Effects of Insulin on Pancreatic Cancer Cells and Disturbs Host Energy Homeostasis
Intratumoral hypoxia and paracrine insulin stimulate the expression of hypoxia inducible factor-1α (HIF-1α) in pancreatic cancer cells. In the present studies, we investigated whether insulin-induced HIF-1α expression is a prerequisite for insulin to induce other trophic effects in MiaPaCa2 human pa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1851851/ https://ncbi.nlm.nih.gov/pubmed/17255315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060489 |
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