The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor.

Interleukin-1 (IL-1) is a major proinflammatory cytokine produced by monocytes/macrophages. At the inflammatory site, IL-1 is a potent inducer of the production of prostaglandin E2 (PGE2) and metalloproteinases on fibroblast-like cells, thus triggering tissue damage. The biological activity of IL-1...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Burger, D, Chicheportiche, R, Giri, J G, Dayer, J M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7615809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118045
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