Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.

The tyrosine kinase activity of insulin receptor isolated from the skeletal muscle of NIDDM patients has previously been found to be decreased compared with the activity of receptor from nondiabetic subjects but the mechanism underlying this defect is unknown. Phosphorylation of receptor serine/thre...

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Pubblicato in:	J Clin Invest
Autori principali:	Kellerer, M, Coghlan, M, Capp, E, Mühlhöfer, A, Kroder, G, Mosthaf, L, Galante, P, Siddle, K, Häring, H U
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC185166/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7615833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118073
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