Accelerated in Vivo Growth of Prostate Tumors that Up-Regulate Interleukin-6 Is Associated with Reduced Retinoblastoma Protein Expression and Activation of the Mitogen-Activated Protein Kinase Pathway

Interleukin-6 (IL-6) is a multifunctional cytokine that activates the signaling pathways of Janus kinases-signal transducers and activators of transcription (STAT) and/or mitogen-activated protein kinases (MAPK) in various tumors. Thus, it modulates cell growth and apoptosis. IL-6 levels are elevate...

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Main Authors: Steiner, Hannes, Godoy-Tundidor, Sonia, Rogatsch, Hermann, Berger, Andreas P., Fuchs, Dietmar, Comuzzi, Barbara, Bartsch, Georg, Hobisch, Alfred, Culig, Zoran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851151/
https://ncbi.nlm.nih.gov/pubmed/12547723
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