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Down-Regulation of Sonic Hedgehog Expression in Pulmonary Hypoplasia Is Associated with Congenital Diaphragmatic Hernia

The pathogenesis of pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) is unknown. The sonic hedgehog (Shh) cascade is crucial for the patterning of the early respiratory system in mice. To establish whether Shh plays a role in the pathogenesis of lung hypoplasia in CDH, we i...

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Detalhes bibliográficos
Main Authors: Unger, Sharon, Copland, Ian, Tibboel, Dick, Post, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851145/
https://ncbi.nlm.nih.gov/pubmed/12547712
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