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Down-Regulation of Sonic Hedgehog Expression in Pulmonary Hypoplasia Is Associated with Congenital Diaphragmatic Hernia

The pathogenesis of pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) is unknown. The sonic hedgehog (Shh) cascade is crucial for the patterning of the early respiratory system in mice. To establish whether Shh plays a role in the pathogenesis of lung hypoplasia in CDH, we i...

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Autores principales: Unger, Sharon, Copland, Ian, Tibboel, Dick, Post, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851145/
https://ncbi.nlm.nih.gov/pubmed/12547712
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