Low Frequency of FAS Mutations in Reed-Sternberg Cells of Hodgkin’s Lymphoma

Reed-Sternberg (RS) cells, the neoplastic elements of Hodgkin’s lymphoma (HL), usually lack B-cell receptor expression. Normal germinal center B cells, with lack of or low-affinity B-cell receptor expression, are eliminated via FAS-induced apoptosis. RS cells express FAS, but are rescued from apopto...

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Bibliografske podrobnosti
Main Authors: Maggio, Ewerton M., van den Berg, Anke, de Jong, Debora, Diepstra, Arjan, Poppema, Sibrand
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2003
Teme:
Short Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851130/
https://ncbi.nlm.nih.gov/pubmed/12507887
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