Adenoviral Transfer of Murine Oncostatin M Elicits Periosteal Bone Apposition in Knee Joints of Mice, Despite Synovial Inflammation and Up-Regulated Expression of Interleukin-6 and Receptor Activator of Nuclear Factor-κB Ligand

Oncostatin M (OSM) has been described as a bone-remodeling factor either stimulating osteoblast activity or osteoclast formation in vitro. To elucidate the in vivo effect of OSM on bone remodeling, we injected an adenoviral vector encoding murine OSM in knee joints of mice. OSM strongly induced inte...

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Detalhes bibliográficos
Main Authors: de Hooge, Alfons S. K., van de Loo, Fons A. J., Bennink, Miranda B., de Jong, Diana S., Arntz, Onno J., Lubberts, Erik, Richards, Carl D., van den Berg, Wim B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850853/
https://ncbi.nlm.nih.gov/pubmed/12000725
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