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Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120

The HIV-1 envelope glycoprotein gp120 interacts consecutively with CD4 and the CCR5 coreceptor to mediate the entry of certain HIV-1 strains into target cells. Acidic residues and sulfotyrosines in the amino-terminal domain (Nt) of CCR5 are crucial for viral fusion and entry. We tested the binding o...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cormier, Emmanuel G., Persuh, Marjan, Thompson, Daniah A. D., Lin, Steven W., Sakmar, Thomas P., Olson, William C., Dragic, Tatjana
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18507/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10823934/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.11.5762
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