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Significant Impact of Promoter Hypermethylation and the 540 C>T Polymorphism of CDKN2A in Cutaneous Melanoma of the Vertical Growth Phase

Promoter hypermethylation, mutations, and loss of heterozygosity in the CDKN2A gene as well as polymorphisms at the 3′-untranslated region were determined in vertical growth phase melanomas. Methylation-specific polymerase chain reaction in soluti and in situ showed that 19% of the cases were hyperm...

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Библиографические подробности
Главные авторы: Straume, Oddbjørn, Smeds, Johanna, Kumar, Rajiv, Hemminki, Kari, Akslen, Lars Andreas
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2002
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850679/
https://ncbi.nlm.nih.gov/pubmed/12107107
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