CD2AP Localizes to the Slit Diaphragm and Binds to Nephrin via a Novel C-Terminal Domain

CD2AP, an adapter protein containing multiple SH3 domains, plays a critical role in kidney function. Mice lacking CD2AP die soon after birth because of kidney failure. In the kidney, CD2AP is expressed in glomerular podocytes, which suggests that it may play a role in a specialized adhesion complex...

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Main Authors: Shih, Neng-Yao, Li, Jun, Cotran, Ramzi, Mundel, Peter, Miner, Jeffrey H., Shaw, Andrey S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2001
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850607/
https://ncbi.nlm.nih.gov/pubmed/11733379
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