β-Catenin Dysregulation in Thyroid Neoplasms : Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis

β-catenin has a role in cell adhesion and Wnt signaling. It is mutated or otherwise dysregulated in a variety of human cancers. In this study we assess β-catenin alteration in 145 thyroid tumors samples from 127 patients. β-catenin was localized using immunofluorescence and mutational analysis was p...

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Bibliographic Details
Main Authors: Garcia-Rostan, Ginesa, Camp, Robert L., Herrero, Agustin, Carcangiu, Maria Luisa, Rimm, David L., Tallini, Giovanni
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850336/
https://ncbi.nlm.nih.gov/pubmed/11238046
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